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KMID : 0366219730080020019
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Korean Journal of Hematology
1973 Volume.8 No. 2 p.19 ~ p.28
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Histiocytic Medullary Reticulosis - Report of an Autopsy Case with Literature Review -
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홍성황(洪性簧)/S.W. Hong
지영일(池英一)/김노경(金潞經)/이문호(李文鎬)/지현숙(池賢淑)/김상인(金相仁)/이정빈(李正彬)/Y.I. Chi/N.K. Kim/M.H. Lee/J.B. Lee/H.S. Chi/S.I. Kim
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Abstract
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An autopsy-verified case of histiocytic medullary reticulosis occuring in an nineteen
year-old. Korean male was presented, and its clinico-pathologic characteristics were
discussed with brief literature review.
The clinical course and rapid fatal outcome as with hematological features were
basically identical to those of previously documented histiocytic medullary reticulosis of
Robb-Smith; instead of peculiar clinical manifestations such as meager lymphadenopathy,
lack of splenomegaly and prominent bleeding tendency with strong evidence of
coagulopathy, antemortem diagnosis was possible by close correlation with findings of
peripheral blood smears and repeated bone marrow aspirations. On autopsy, the lesions
were found to be systemic and exhibited non-tumefied proliferative growth of atypical
histiocytes and their precursor cells engaged in active erythrophagocytosis. Organ
involvement was mainly confined to liver, spleen, lymph nodes and bone marrow, but
rest of tissues were also slightly affected as well.
It is of authors' opinion that extensive and thorough coagulation studies should be
followed for better understanding of this disorder.
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KEYWORD
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